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TEPP-46是重组丙酮酸激酶M2（PKM2）的有效选择性活化剂，最大活化浓度（AC50值）的一半为92 nM，相对于PKM1，PKL和PKR几乎没有或没有活性。
| In vitro | DMSO | 73 mg/mL (195.99 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.85 mL | 134.24 mL | 268.49 mL |
| 0.5 mM | 5.37 mL | 26.85 mL | 53.7 mL |
| 1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
*The above data is based on the productmolecular weight 372.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16279 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 372.46 |
| Formula | C17H16N4O2S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1221186-53-3 |
| Synonyms | ML-265 |
| SMILES | O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4 |
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