Teprotumumab is a human monoclonal antibody that acts as an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R). This antibody specifically targets and binds to the extracellular ??-subunit domain of IGF-1R, which is crucial for its ligand-binding activity. By doing so, Teprotumumab effectively blocks the receptor's interaction with its ligands, thereby inhibiting downstream signaling pathways. The antibody has been shown to impede both thyroid-stimulating hormone (TSH) and IGF-1 mediated actions in fibrocytes, leading to a reduction in TSH-dependent interleukin-6 (IL-6) and interleukin-8 (IL-8) expression, as well as Akt phosphorylation. Teprotumumab is primarily utilized in research focused on thyroid-associated ophthalmopathy, providing a valuable tool for studying the pathophysiology and potential therapeutic interventions for this condition.
Teprotumumab is a human monoclonal antibody that acts as an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R). This antibody specifically targets and binds to the extracellular ??-subunit domain of IGF-1R, which is crucial for its ligand-binding activity. By doing so, Teprotumumab effectively blocks the receptor's interaction with its ligands, thereby inhibiting downstream signaling pathways. The antibody has been shown to impede both thyroid-stimulating hormone (TSH) and IGF-1 mediated actions in fibrocytes, leading to a reduction in TSH-dependent interleukin-6 (IL-6) and interleukin-8 (IL-8) expression, as well as Akt phosphorylation. Teprotumumab is primarily utilized in research focused on thyroid-associated ophthalmopathy, providing a valuable tool for studying the pathophysiology and potential therapeutic interventions for this condition.
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