TG-101348 (Fedratinib, SAR302503)

目录号: A11082

JAK2 抑制剂

TG-101348 (Fedratinib, SAR302503) Chemical Structure

CAS NO. 936091-26-8

TG-101348是Janus相关激酶2的口服生物利用型,ATP竞争性和选择性抑制剂,在无细胞试验中IC50为3 nM,作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,具有潜在的抗肿瘤活性。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 3,200.00
100 mg
¥ 5,800.00
10mM * 1mL in DMSO
¥ 1,220.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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TG-101348是Janus相关激酶2的口服生物利用型,ATP竞争性和选择性抑制剂,在无细胞试验中IC50为3 nM,作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,具有潜在的抗肿瘤活性。
靶点信息
JAK2 (Cell-free assay) JAK2 (V617F) (Cell-free assay) FLT3 (Cell-free assay) RET (Cell-free assay)
3 nM3 nM15 nM48 nM
In vitro (25°C) DMSO 100 mg/mL (190.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.06 mL 95.29 mL 190.59 mL
0.5 mM 3.81 mL 19.06 mL 38.12 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
5 mM 0.38 mL 1.91 mL 3.81 mL

*The above data is based on the productmolecular weight 524.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11082
MECHANISM OF ACTION Inhibitor
M. Wt 524.7
Formula C27H36N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936091-26-8
Synonyms SAR302503,TG101348,TG101348
SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

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