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TG-101348 (Fedratinib, SAR302503)

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JAK2 抑制剂

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产品目录号： A11082

库存状态：中国现货中国现货

产品名 目录号 价格 数量
TG-101348 5mg A11082-5
￥ 600.00
TG-101348 10mg A11082-10
￥ 1,000.00
TG-101348 50mg A11082-50
￥ 3,200.00
TG-101348 100mg A11082-100
￥ 5,800.00
TG-101348 10mM * 1mL in DMSO A11082-10mM-D
￥ 1,220.00

产品仅用于研究，不针对患者销售，望谅解.

产品简介

TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.

TG-101348 (Fedratinib, SAR302503)

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Chemical Information

目录号 A11082
Mechanism of action Inhibitor
分子量 524.7
化学分子式 C27H36N6O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 936091-26-8
Synonyms SAR302503,TG101348,TG101348
SMILES code CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
化学名称 N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide

生物活性

Description
 TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.
Targets
JAK2 (Cell-free assay) JAK2 (V617F) (Cell-free assay) FLT3 (Cell-free assay) RET (Cell-free assay)
3 nM3 nM15 nM48 nM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (190.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.06 mL 95.29 mL 190.59mL
0.5 mM 3.81 mL 19.06 mL 38.12 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
5 mM 0.38 mL 1.91 mL 3.81 mL

*The above data is based on the productmolecular weight 524.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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