TG101209

目录号: A11180

JAK2 抑制剂

TG101209 Chemical Structure

CAS NO. 936091-14-4

TG101209是一种新型的JAK2抑制剂,无细胞试验中IC50为6 nM,对Flt3和RET作用效果稍弱,IC50分别为25 nM和17 nM,作用于JAK2比作用于JAK3选择性高30倍左右,对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性,并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,200.00
50 mg
¥ 2,700.00
100 mg
¥ 4,850.00
10mM * 1mL in DMSO
¥ 1,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

TG101209是一种新型的JAK2抑制剂,无细胞试验中IC50为6 nM,对Flt3和RET作用效果稍弱,IC50分别为25 nM和17 nM,作用于JAK2比作用于JAK3选择性高30倍左右,对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性,并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。
靶点信息
JAK2 (Cell-free assay) RET (Cell-free assay) FLT3 (Cell-free assay) JAK3 (Cell-free assay)
6 nM17 nM25 nM169 nM
In vitro (25°C) DMSO 102 mg/mL (200.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.62 mL 98.1 mL 196.21 mL
0.5 mM 3.92 mL 19.62 mL 39.24 mL
1 mM 1.96 mL 9.81 mL 19.62 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

*The above data is based on the productmolecular weight 509.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11180
MECHANISM OF ACTION Inhibitor
M. Wt 509.67
Formula C26H35N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936091-14-4
Synonyms TG-101209
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3N=C(NC4=CC(=CC=C4)S(=O)(=O)NC(C)(C)C)C(C)=CN=3

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