TH5487
目录号: A18537
OGG1 抑制剂
TH5487 是一种强效的8-氧鸟嘌呤DNA糖苷酶1（OGG1）抑制剂，其IC50为342 nM。TH5487 阻止 OGG1 识别其 DNA 底物，抑制 DNA 修复，并改变 OGG1 的染色质动态，从而导致抑制 炎症途径基因。
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生物活性
| Discription | TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes. |
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产品信息
| 目录号 | A18537 |
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| 分子式 | C19H18BrIN4O2 |
| 分子量 | 541.18 |
| CAS号 | 2304947-71-3 |
| SMILES | O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4 |
| 其他名称 | TH 5487; TH5487; TH-5487 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 9 mg/mL (16.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.48 mL | 92.39 mL | 184.78 mL |
| 0.5 mM | 3.7 mL | 18.48 mL | 36.96 mL |
| 1 mM | 1.85 mL | 9.24 mL | 18.48 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.7 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 2304947-71-3 | 2304947-71-3 供应商 | 2304947-71-3 花费 | 2304947-71-3 生产商 | 订购 2304947-71-3 | 2304947-71-3 代理商