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TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.
| In vitro | DMSO | 9 mg/mL (16.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.48 mL | 92.39 mL | 184.78 mL |
| 0.5 mM | 3.7 mL | 18.48 mL | 36.96 mL |
| 1 mM | 1.85 mL | 9.24 mL | 18.48 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.7 mL |
*The above data is based on the productmolecular weight 541.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18537 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 541.18 |
| Formula | C19H18BrIN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2304947-71-3 |
| Synonyms | TH 5487; TH5487; TH-5487 |
| SMILES | O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4 |
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