Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
Targets
Target
Value
产品信息
目录号
A12144
分子式
C13H9FN2O4
分子量
276.22
CAS号
835616-60-9
SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O
其他名称
Cereblon ligand 4; E3 ligase Ligand 4
储存条件
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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