Tidutamab (XmAb-18087) is a humanized, affinity-optimized bispecific antibody designed to target both the somatostatin receptor 2 (SSTR2) and the CD3 epsilon subunit of the T-cell receptor. This antibody features a complete Fc domain, which enhances its stability and prolongs its serum half-life. Tidutamab facilitates the elimination of SSTR2-expressing tumor cells through the mechanism of redirected T-cell-mediated cytotoxicity (RTcC), offering a targeted approach in cancer immunotherapy.
Tidutamab (XmAb-18087) is a humanized, affinity-optimized bispecific antibody designed to target both the somatostatin receptor 2 (SSTR2) and the CD3 epsilon subunit of the T-cell receptor. This antibody features a complete Fc domain, which enhances its stability and prolongs its serum half-life. Tidutamab facilitates the elimination of SSTR2-expressing tumor cells through the mechanism of redirected T-cell-mediated cytotoxicity (RTcC), offering a targeted approach in cancer immunotherapy.
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