Tilavonemab (ABBV-8E12) is a humanized monoclonal antibody designed to target and neutralize extracellular pathological tau protein aggregates. It specifically binds to the N-terminal 25-30 amino acid residues of the tau protein. This interaction inhibits the uptake of tau aggregates by human and mouse neurons, mitigates brain volume loss, decelerates the progression of tau pathology, and enhances cognitive functions in transgenic mice models expressing mutant human tau. Tilavonemab is primarily utilized in research focused on Alzheimer's disease, offering significant insights into the mechanisms of tau-related neurodegeneration and potential therapeutic interventions.
Tilavonemab (ABBV-8E12) is a humanized monoclonal antibody designed to target and neutralize extracellular pathological tau protein aggregates. It specifically binds to the N-terminal 25-30 amino acid residues of the tau protein. This interaction inhibits the uptake of tau aggregates by human and mouse neurons, mitigates brain volume loss, decelerates the progression of tau pathology, and enhances cognitive functions in transgenic mice models expressing mutant human tau. Tilavonemab is primarily utilized in research focused on Alzheimer's disease, offering significant insights into the mechanisms of tau-related neurodegeneration and potential therapeutic interventions.
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