Tilvestamab (BGB149) is a humanized monoclonal antibody specifically targeting the AXL receptor tyrosine kinase. By effectively blocking AXL-mediated signaling pathways, Tilvestamab significantly reduces Gas6-induced AXL activation in 786-0-Luc renal cell carcinoma (RCC) cells and subsequently inhibits AKT phosphorylation. This antibody is particularly valuable in cancer research focusing on conditions characterized by overexpression of AXL, such as renal cell carcinomas.
Tilvestamab (BGB149) is a humanized monoclonal antibody specifically targeting the AXL receptor tyrosine kinase. By effectively blocking AXL-mediated signaling pathways, Tilvestamab significantly reduces Gas6-induced AXL activation in 786-0-Luc renal cell carcinoma (RCC) cells and subsequently inhibits AKT phosphorylation. This antibody is particularly valuable in cancer research focusing on conditions characterized by overexpression of AXL, such as renal cell carcinomas.
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