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Timegadine被发现是一种有效的竞争性环加氧酶（COX）和脂加氧酶抑制剂，IC50的范围从5 nM（洗兔血小板）到20μM（大鼠脑）。在马血小板匀浆的细胞溶质级分和洗涤过的兔血小板中，脂氧化酶的浓度为100μM和100μM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.36 mL | 136.8 mL | 273.6 mL |
| 0.5 mM | 5.47 mL | 27.36 mL | 54.72 mL |
| 1 mM | 2.74 mL | 13.68 mL | 27.36 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
*The above data is based on the productmolecular weight 365.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17108 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 365.5 |
| Formula | C20H23N5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 71079-19-1 |
| Synonyms | SR 1368, SR-1368, SR1368 |
| SMILES | CC1=NC2=CC=CC=C2C(/N=C(NC3CCCCC3)/NC4=NC=CS4)=C1 |
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