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Tipifarnib (Zarnestra)


FTase 抑制剂

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产品目录号: A10935


产品名 目录号 价格 数量
Tipifarnib 5mg A10935-5
¥ 1,500.00
Tipifarnib 10mg A10935-10
¥ 2,500.00
Tipifarnib 25mg A10935-25
¥ 4,500.00
Tipifarnib 100mg A10935-100
¥ 8,000.00
Tipifarnib (Zarnestra) 10mM * 1mL in DMSO A10935-10mM-D
¥ 2,060.00



Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.

Tipifarnib (Zarnestra)




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Chemical Information

目录号 A10935
Mechanism of action Inhibitor
分子量 489.4
化学分子式 C27H22Cl2N4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 192185-72-1
Synonyms IND 58359, R115777
SMILES code CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
化学名称 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one


Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
0.6 nM


Solubility (25°C) * In vitro DMSO 14 mg/mL (28.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.17 mL 204.33mL
0.5 mM 4.09 mL 20.43 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

*The above data is based on the productmolecular weight 489.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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A11002YM15589 mg/mL55 mg/mL6 mg/mL
A10935Tipifarnib (Zarnestra)<1 mg/mL83 mg/mL<1 mg/mL
A10657Nutlin-3<1 mg/mL116 mg/mL116 mg/mL

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