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Tivozanib (AV-951)



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产品目录号: A10101


产品名 目录号 价格 数量
Tivozanib 5mg A10101-5
¥ 400.00
Tivozanib 10mg A10101-10
¥ 700.00
Tivozanib 25mg A10101-25
¥ 1,200.00
Tivozanib 50mg A10101-50
¥ 1,800.00
Tivozanib (AV-951) 10mM * 1mL in DMSO A10101-10mM-D
¥ 950.00



Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.

Tivozanib (AV-951)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Tivozanib (AV-951) 发表的文献 (4)
  • Majid Momeny, .et al. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells, Sci Rep, 2017, 7: 45954 PMID: 28383032
  • Majid Momeny, .et al. Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells, Sci Rep, 2017, 7: 44075 PMID: 28287096
  • Nicholas A. Manieri, .et al. Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis, J Clin Invest, 2015, Sep 1; 125(9): 3606每3618 PMID: 26280574
  • Usui T, .et al. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells., Acta Physiol (Oxf), 2014, 211, 385每394 PMID: 24612679

Chemical Information

目录号 A10101
Mechanism of action Inhibitor
分子量 454.9
化学分子式 C22H19ClN4O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 475108-18-0
Synonyms AV-951, AV951
SMILES code CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
化学名称 1-{2-Chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methylisoxazol-3-yl)urea


Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.
Target Value
VEGFR2IC50: 6.5nM
VEGFR3IC50: 15nM
EphB2IC50: 24nM
VEGFR1IC50: 30nM
PDGFRαIC50: 40nM
PDGFRβIC50: 49nM
c-KitIC50: 78nM
Tie-2IC50: 78nM
EphB4IC50: 480nM
FGFR1IC50: 530nM
c-MetIC50: 550nM
AblIC50: 620nM
SrcIC50: 960nM
FGFR3IC50: >1μM
FGFR4IC50: >1μM
FLT3IC50: >1μM
EGFRIC50: >1μM
ErbB2IC50: >1μM
Insulin ReceptorIC50: >1μM
FAKIC50: >1μM
ErbB4IC50: >1μM
IGF-1RIC50: >1μM
JAK2IC50: >1μM


Solubility (25°C) * In vitro DMSO 20 mg/mL (43.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.98 mL 109.91 mL 219.83mL
0.5 mM 4.4 mL 21.98 mL 43.97 mL
1 mM 2.2 mL 10.99 mL 21.98 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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