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TNP is a cell-permeable inhibitor of IP6K1 and IP3K, with IC50 values of 0.55 ?M and 10.2 ?M for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.77 mL | 225.54 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.11 mL |
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19891 |
|---|---|
| M. Wt | 443.38 |
| Formula | C20H16F3N7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 519178-28-0 |
| SMILES | FC(C1=CC(CNC2=NC(NCC3=CC=C([N+]([O-])=O)C=C3)=C4N=CNC4=N2)=CC=C1)(F)F |
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