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Torin 1


mTOR 抑制剂

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产品目录号: A11587


产品名 目录号 价格 数量
Torin 1 10mg A11587-10
¥ 900.00
Torin 1 25mg A11587-25
¥ 1,800.00
Torin 1 50mg A11587-50
¥ 3,000.00
Torin 1 100mg A11587-100
¥ 5,200.00



Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.

Torin 1




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Torin 1 发表的文献 (2)
  • Ashyad Rayhan, .et al. Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function, Biol Open, 2018, Jan 15; 7(1): bio031302 PMID: 29343513
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422

Chemical Information

目录号 A11587
Mechanism of action Inhibitor
分子量 607.62
化学分子式 C35H28F3N5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1222998-36-8
Synonyms Torin1
SMILES code CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
化学名称 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one


Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
Target Value
mTORC1IC50: 2nM
mTORIC50: 4.32nM
DNA-PKIC50: 6.34nM
mTORC2IC50: 10nM
p110γIC50: 171nM
C2αIC50: 176nM
p110α/p85αIC50: 250nM
hVPS34IC50: 533nM
C2βIC50: 549nM
p110δ/p85αIC50: 564nM
PI4KβIC50: 6680nM
PI4KαIC50: >10μM


Solubility (25°C) * In vitro DMSO 2 mg/mL (3.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.46 mL 82.29 mL 164.58mL
0.5 mM 3.29 mL 16.46 mL 32.92 mL
1 mM 1.65 mL 8.23 mL 16.46 mL
5 mM 0.33 mL 1.65 mL 3.29 mL

*The above data is based on the productmolecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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