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Torin 2

mTOR 抑制剂

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产品目录号: A11586


产品名 目录号 价格 数量
Torin 2 10mg A11586-10
¥ 1,100.00
Torin 2 25mg A11586-25
¥ 2,000.00
Torin 2 50mg A11586-50
¥ 3,300.00
Torin 2 100mg A11586-100
¥ 4,900.00
Torin 2 10mM * 1mL in DMSO A11586-10mM-D
¥ 1,110.00



Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).

Torin 2




顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A11586
Mechanism of action Inhibitor
分子量 432.4
化学分子式 C24H15F3N4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1223001-51-1
Synonyms Torin2
SMILES code C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
化学名称 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one


Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
mTOR (p53?/? MEFs) ATM (PC3 cells) ATR (PC3 cells) DNA-PK (PC3 cells)
0.25 nM28 nM(EC50)35 nM(EC50)118 nM(EC50)


Solubility (25°C) * In vitro DMSO 20 mg/mL (46.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.13 mL 115.63 mL 231.27mL
0.5 mM 4.63 mL 23.13 mL 46.25 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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