Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody engineered to specifically neutralize the alpha-toxin (alpha-hemolysin; Hla) produced by Staphylococcus aureus. By targeting an N-terminal epitope of alpha-toxin, Tosatoxumab inhibits the oligomerization process essential for the formation of functional toxin pores. This antibody offers promising applications in passive immunotherapy for Staphylococcus aureus pneumonia, serving as an adjunctive treatment alongside standard antibiotic therapies.
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody engineered to specifically neutralize the alpha-toxin (alpha-hemolysin; Hla) produced by Staphylococcus aureus. By targeting an N-terminal epitope of alpha-toxin, Tosatoxumab inhibits the oligomerization process essential for the formation of functional toxin pores. This antibody offers promising applications in passive immunotherapy for Staphylococcus aureus pneumonia, serving as an adjunctive treatment alongside standard antibiotic therapies.
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