Dubermatinib (TP-0903)
目录号: A15776
AXL 抑制剂
TP-0903 是一种强效且选择性的 Axl激酶抑制剂,其 IC50 为 27 nM。
| Discription | TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM. | |||||
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| 目录号 | A15776 |
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| 分子式 | C24H30ClN7O2S |
| 分子量 | 516.06 |
| CAS号 | 1341200-45-0 |
| SMILES | CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl |
| 其他名称 | TP0903, TP 0903 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | Warmed: 3 mg/mL (5.81 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 1 mg/mL (1.93 mM) | ||
| In vivo | 0.5% CMC Na+1% Tween 80 | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.38 mL | 96.89 mL | 193.78 mL |
| 0.5 mM | 3.88 mL | 19.38 mL | 38.76 mL |
| 1 mM | 1.94 mL | 9.69 mL | 19.38 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2