TP0427736 HCl

Name: TP0427736 HCl
SKU: A22382
Price: 630 CNY
Rating: 5 (288 reviews)

目录号: A22382

ALK5 抑制剂

TP0427736 是一种强效的 ALK5 激酶活性抑制剂，其 IC50 值为 2.72 nM，其抑制效果比对 ALK3 的抑制效果高出 300 倍（ALK3 的 IC50 值为 836 nM）。它还能抑制由 TGF-β1 诱导的 A549 细胞中 Smad2/3 磷酸化，其 IC50 值为 8.68 nM。

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规格	价格	库存
2mg	¥630.00	现货
5mg	¥700.00	现货
10mg	¥1,120.00	现货
25mg	¥2,170.00	现货
50mg	¥3,465.00	现货
100mg	¥5,670.00	现货
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Data Sheet

SDS

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生物活性

Discription	TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.

产品信息

目录号	A22382
分子式	C14H11ClN4S2
分子量	334.85
CAS号	2459963-17-6 (HCl), 864374-00-5
SMILES	CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4.Cl
其他名称	TP 0427736 HCl,TP-0427736 HCl
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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