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IKK-2 抑制剂

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产品目录号: A11579


产品名 目录号 价格 数量
TPCA-1 10mg A11579-10
¥ 1,200.00
TPCA-1 25mg A11579-25
¥ 2,500.00
TPCA-1 50mg A11579-50
¥ 4,200.00
TPCA-1 100mg A11579-100
¥ 7,000.00
TPCA-1 10mM * 1mL in DMSO A11579-10mM-D
¥ 930.00



TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.





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Chemical Information

目录号 A11579
Mechanism of action Inhibitor
分子量 279.29
化学分子式 C12H10FN3O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 507475-17-4
Synonyms TPCA1
SMILES code C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F
化学名称 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide


TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
IKK2 (Cell-free assay)
17.9 nM


Solubility (25°C) * In vitro DMSO 56 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.81 mL 179.03 mL 358.05mL
0.5 mM 7.16 mL 35.81 mL 71.61 mL
1 mM 3.58 mL 17.9 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL

*The above data is based on the productmolecular weight 279.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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