Trabikibart (CSL311) is a ??c (CSF2RB)-specific, fully human monoclonal antibody engineered to target a unique epitope on the cytokine-binding site of the human ??c receptor. Exhibiting a picomolar binding affinity, this antibody effectively binds to the receptor, demonstrating robust specificity. Trabikibart acts as a potent inhibitor of the combined biological activities of IL-3, GM-CSF, and IL-5, particularly impacting the survival of eosinophils. This characteristic positions Trabikibart as a valuable tool for investigating the mechanisms underlying chronic inflammatory diseases and exploring potential therapeutic interventions.
Trabikibart (CSL311) is a ??c (CSF2RB)-specific, fully human monoclonal antibody engineered to target a unique epitope on the cytokine-binding site of the human ??c receptor. Exhibiting a picomolar binding affinity, this antibody effectively binds to the receptor, demonstrating robust specificity. Trabikibart acts as a potent inhibitor of the combined biological activities of IL-3, GM-CSF, and IL-5, particularly impacting the survival of eosinophils. This characteristic positions Trabikibart as a valuable tool for investigating the mechanisms underlying chronic inflammatory diseases and exploring potential therapeutic interventions.
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