TRAM-34
TRAM-34 是一种高度选择性的中间电导钙激活钾通道（KCa3.1）阻断剂（Kd = 20 nM）。相较于 KV、BKCa、KCa2、Na+、CRAC 和 Cl- 通道，展现出 200-1500 倍的选择性。能够抑制淋巴细胞对有丝分裂刺激的再激活。
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生物活性
| Discription | TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli. | |||||
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产品信息
| 目录号 | A12783 |
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| 分子式 | C22H17ClN2 |
| 分子量 | 344.84 |
| CAS号 | 289905-88-0 |
| SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4 |
| 其他名称 | TRAM34, TRAM 34 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 0.36 mg/mL (1.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+corn oil | 1 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29 mL | 144.99 mL | 289.99 mL |
| 0.5 mM | 5.8 mL | 29 mL | 58 mL |
| 1 mM | 2.9 mL | 14.5 mL | 29 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.8 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 TRAM-34 | TRAM-34 供应商 | TRAM-34 花费 | TRAM-34 生产商 | 订购 TRAM-34 | TRAM-34 代理商
| 购买 289905-88-0 | 289905-88-0 供应商 | 289905-88-0 花费 | 289905-88-0 生产商 | 订购 289905-88-0 | 289905-88-0 代理商