TSU-68 (Orantinib, SU6668)

Name: TSU-68 (Orantinib, SU6668)
SKU: A10953
Price: 140 CNY
Rating: 5 (2 reviews)

目录号: A10953

PDFGRβ 抑制剂

2 篇发表文献

Orantinib (TSU-68, SU6668) 在无细胞实验中对 PDGFR自磷酸化 具有最高的抑制活性，Ki 值为 8 nM，但也强烈抑制 Flk-1 和 FGFR1跨磷酸化，对 IGF-1R、Met、Src、Lck、Zap70、Abl 和 CDK2 活性较弱；不抑制 EGFR。处于第三阶段临床试验。

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Grouped product items
规格	价格	库存
1mg	¥140.00	现货
5mg	¥280.00	现货
10mg	¥455.00	现货
25mg	¥1,015.00	现货
50mg	¥1,995.00	现货
100mg	¥3,185.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用TSU-68 (Orantinib, SU6668)发表的2篇文献

Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932

Aaron Y. Lai, .et al. , Brain, 2015, Apr;138(Pt 4):1046-58 PMID: 25688079

生物活性

Discription

Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.

Targets

Target	Value

产品信息

目录号	A10953
分子式	C18H18N2O3
分子量	310.4
CAS号	252916-29-3
SMILES	CC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O
其他名称	TSU68
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	55 mg/mL (177.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.22 mL	161.08 mL	322.16 mL
0.5 mM	6.44 mL	32.22 mL	64.43 mL
1 mM	3.22 mL	16.11 mL	32.22 mL
5 mM	0.64 mL	3.22 mL	6.44 mL

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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