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Tubacin

HDAC6 抑制剂

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产品目录号: A10954

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Tubacin 5mg A10954-5
¥ 2,500.00
Tubacin 10mg A10954-10
¥ 4,700.00
Tubacin 25mg A10954-25
¥ 9,500.00
Tubacin 50mg A10954-50
¥ 15,000.00
Tubacin 10mM * 1mL in DMSO A10954-10mM-D
¥ 4,920.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM.

Tubacin

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Chemical Information

目录号 A10954
Mechanism of action Inhibitor
分子量 721.9
化学分子式 C41H43N3O7S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 537049-40-4
Synonyms N/A
SMILES code C1[C@@H](O[C@@H](O[C@@H]1C2=CC=C(C=C2)CO)C3=CC=C(C=C3)NC(=O)CCCCCCC(=O)NO)CSC4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6
化学名称 N1-(4-((2R,4R,6S)-4-(((4,5-diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide

生物活性

Description
Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM.
Targets
HDAC6 (Cell-free assay)
4 nM

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (138.53 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.85 mL 69.26 mL 138.52mL
0.5 mM 2.77 mL 13.85 mL 27.7 mL
1 mM 1.39 mL 6.93 mL 13.85 mL
5 mM 0.28 mL 1.39 mL 2.77 mL

*The above data is based on the productmolecular weight 721.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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