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Tubulysin

Tubulysin

Name: Tubulysin
SKU: A18475

目录号: A18475

microtubule destabilizing agents

Tubulysin Chemical Structure

CAS NO. 1943604-24-7

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system.

库存：现货

规格	价格	数量
5 mg	￥ 3,500.00
10 mg	￥ 6,500.00
50 mg	￥ 20,000.00

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制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.88 mL	59.38 mL	118.75 mL
0.5 mM	2.38 mL	11.88 mL	23.75 mL
1 mM	1.19 mL	5.94 mL	11.88 mL
5 mM	0.24 mL	1.19 mL	2.38 mL

*The above data is based on the productmolecular weight 842.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18475
M. Wt	842.1
Formula	C44H67N5O9S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1943604-24-7
SMILES	O=C(O)[C@@H](C)C[C@@H](NC(C1=CSC([C@H](OC(C)=O)C[C@@H](N(COC(CC(C)C)=O)C([C@@H](NC([C@@H]2N(C)CCCC2)=O)[C@@H](C)CC)=O)C(C)C)=N1)=O)CC3=CC=C(C)C=C3