产品详情
U0126-EtOH是MEK1和MEK2的抑制剂,IC50分别为72 nM和58 nM。
Targets
Target | Value |
---|---|
MEK2 | IC50: 0.06μM |
MEK1 | IC50: 0.07μM |
PKC | IC50: >10μM |
CDK2 | IC50: >10μM |
CDK4 | IC50: >10μM |
MKK6/p38MAPK | IC50: 20μM |
MKK3/p38MAPK | IC50: 38μM |
ERK1/2 | IC50: >50μM |
JNK | IC50: >100μM |
MKK4 | IC50: >100μM |
Abl | IC50: >100μM |
In vitro (25°C) | DMSO | Warmed: 77 mg/mL (180.51 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5%DMSO+40%PEG300+5%Tween 80+50%H2O | 4.03 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.44 mL | 117.21 mL | 234.41 mL |
0.5 mM | 4.69 mL | 23.44 mL | 46.88 mL |
1 mM | 2.34 mL | 11.72 mL | 23.44 mL |
5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10957 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 426.6 |
Formula | C18H16N6S2.C2H6O |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1173097-76-1 |
SMILES | CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
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