产品详情
Targets
Target | Value |
---|---|
MEK2 | IC50: 0.06μM |
MEK1 | IC50: 0.07μM |
PKC | IC50: >10μM |
CDK2 | IC50: >10μM |
CDK4 | IC50: >10μM |
MKK6/p38MAPK | IC50: 20μM |
MKK3/p38MAPK | IC50: 38μM |
ERK1/2 | IC50: >50μM |
JNK | IC50: >100μM |
MKK4 | IC50: >100μM |
Abl | IC50: >100μM |
In vitro (25°C) | DMSO | 85 mg/mL (199.26 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide | 30 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.44 mL | 117.21 mL | 234.41 mL |
0.5 mM | 4.69 mL | 23.44 mL | 46.88 mL |
1 mM | 2.34 mL | 11.72 mL | 23.44 mL |
5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10957 |
---|---|
MECHANISM OF ACTION | Inhibitor |
M. Wt | 426.6 |
Formula | C18H16N6S2.C2H6O |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1173097-76-1 |
Synonyms | N/A |
SMILES | CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
产品标签
Product Questions
Product Questions
AZD6244 (Selumetinib)
Selumetinib (AZD6244)是一种有效,高选择性的MEK抑制剂,ARRY142886,AZD-6244和ARRY-142886是MEK 1/2抑制剂,GI50值在14…
SCH772984
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
PD 198306
PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor.
SL-327
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain pe…
MEK162 (ARRY-438162, Binimetinib)
MEK162 (ARRY-438162, Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。