微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
U0126-EtOH是MEK1和MEK2的抑制剂，IC50分别为72 nM和58 nM。
Targets
| Target | Value |
|---|---|
| MEK2 | IC50: 0.06μM |
| MEK1 | IC50: 0.07μM |
| PKC | IC50: >10μM |
| CDK2 | IC50: >10μM |
| CDK4 | IC50: >10μM |
| MKK6/p38MAPK | IC50: 20μM |
| MKK3/p38MAPK | IC50: 38μM |
| ERK1/2 | IC50: >50μM |
| JNK | IC50: >100μM |
| MKK4 | IC50: >100μM |
| Abl | IC50: >100μM |
| In vitro (25°C) | DMSO | 85 mg/mL (199.26 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.44 mL | 117.21 mL | 234.41 mL |
| 0.5 mM | 4.69 mL | 23.44 mL | 46.88 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.44 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10957 |
|---|---|
| MECHANISM OF ACTION | Inhibitor |
| M. Wt | 426.6 |
| Formula | C18H16N6S2.C2H6O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1173097-76-1 |
| Synonyms | N/A |
| SMILES | CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
AZD6244 (Selumetinib)
Selumetinib (AZD6244)是一种有效，高选择性的MEK抑制剂，ARRY142886，AZD-6244和ARRY-142886是MEK 1/2抑制剂，GI50值在14…
SCH772984
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
PD 198306
PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor.
SL-327
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain pe…
MEK162 (ARRY-438162, Binimetinib)
MEK162 (ARRY-438162, Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。
Keywords:购买 U0126-EtOH | U0126-EtOH 供应商 | 订购 U0126-EtOH | U0126-EtOH 价格 | U0126-EtOH 生产商 | 订单 U0126-EtOH | U0126-EtOH 代理商 | 购买 1173097-76-1| 1173097-76-1 供应商 | 订购 1173097-76-1 | 1173097-76-1 价格 | 1173097-76-1 生产商 | 订单 1173097-76-1 | 1173097-76-1 代理商|buy U0126-EtOH | U0126-EtOH Supplier | purchase U0126-EtOH | U0126-EtOH cost | U0126-EtOH manufacturer | order U0126-EtOH | U0126-EtOH distributor | buy 1173097-76-1| 1173097-76-1 Supplier | purchase 1173097-76-1 | 1173097-76-1 cost | 1173097-76-1 manufacturer | order 1173097-76-1 | 1173097-76-1 distributor