U0126-EtOH

目录号: A10957

MEK 抑制剂

U0126-EtOH Chemical Structure

CAS NO. 1173097-76-1

U0126-EtOH是MEK1和MEK2的抑制剂,IC50分别为72 nM和58 nM。

库存: 现货

规格 价格 数量
25 mg
¥ 600.00
50 mg
¥ 800.00
100 mg
¥ 1,100.00
250 mg
¥ 1,800.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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U0126-EtOH是MEK1和MEK2的抑制剂,IC50分别为72 nM和58 nM。
Targets
Target Value
MEK2IC50: 0.06μM
MEK1IC50: 0.07μM
PKCIC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
MKK6/p38MAPKIC50: 20μM
MKK3/p38MAPKIC50: 38μM
ERK1/2IC50: >50μM
JNKIC50: >100μM
MKK4IC50: >100μM
AblIC50: >100μM
In vitro (25°C) DMSO 85 mg/mL (199.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.44 mL 117.21 mL 234.41 mL
0.5 mM 4.69 mL 23.44 mL 46.88 mL
1 mM 2.34 mL 11.72 mL 23.44 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10957
MECHANISM OF ACTION Inhibitor
M. Wt 426.6
Formula C18H16N6S2.C2H6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1173097-76-1
Synonyms N/A
SMILES CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N

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