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U0126-EtOH

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MEK 抑制剂

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产品目录号： A10957

库存状态：中国现货中国现货

产品名 目录号 价格 数量
U0126-EtOH 25mg A10957-25
￥ 600.00
U0126-EtOH 50mg A10957-50
￥ 800.00
U0126-EtOH 100mg A10957-100
￥ 1,100.00
U0126-EtOH 250mg A10957-250
￥ 1,800.00
U0126-EtOH 10mM * 1mL in DMSO A10957-10mM-D
￥ 500.00

产品仅用于研究，不针对患者销售，望谅解.

产品简介

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

U0126-EtOH

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 U0126-EtOH 发表的文献 (2)
  • Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
  • Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Chemical Information

目录号 A10957
Mechanism of action Inhibitor
分子量 426.6
化学分子式 C18H16N6S2.C2H6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1173097-76-1
Synonyms N/A
SMILES code CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
化学名称 (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile; ethanol

生物活性

Description
 U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
Targets
Target Value
MEK2IC50: 0.06μM
MEK1IC50: 0.07μM
PKCIC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
MKK6/p38MAPKIC50: 20μM
MKK3/p38MAPKIC50: 38μM
ERK1/2IC50: >50μM
JNKIC50: >100μM
MKK4IC50: >100μM
AblIC50: >100μM

溶解性

Solubility (25°C) * In vitro DMSO 85 mg/mL (199.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.44 mL 117.21 mL 234.41mL
0.5 mM 4.69 mL 23.44 mL 46.88 mL
1 mM 2.34 mL 11.72 mL 23.44 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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