Umibecestat (CNP520)

Name: Umibecestat (CNP520)
SKU: A18987

目录号: A18987

BACE-1 inhibitor

Umibecestat (CNP520) Chemical Structure

CAS NO. 1387560-01-1

Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.

库存：现货

规格	价格	数量
5 mg	￥ 3,500.00
10 mg	￥ 6,500.00
50 mg	￥ 20,000.00

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生物活性

Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.46 mL	97.31 mL	194.63 mL
0.5 mM	3.89 mL	19.46 mL	38.93 mL
1 mM	1.95 mL	9.73 mL	19.46 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18987
作用机制	Inhibitor (抑制剂)
M. Wt	513.8
Formula	C19H15ClF7N5O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1387560-01-1
Synonyms	CNP 520, CNP-520
SMILES	O=C(NC1=NC([C@@]2(CO[C@](C)(C(N)=N2)C(F)(F)F)C)=C(C=C1)F)C3=NC=C(C=C3Cl)C(F)(F)F