UNC-2025
目录号: A15904
Dual MER/FLT3 抑制剂
UNC-2025 是一种效力强大且可口服的双重 MER/FLT3 抑制剂,其 IC50 分别为 0.74 nM 和 0.8 nM,对 Axl 和 Tyro3 的选择性约为 20 倍。
Discription | UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3. | |||||
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Cell Research |
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目录号 | A15904 |
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分子式 | C28H40N6O |
分子量 | 476.7 |
CAS号 | 1429881-91-3 |
SMILES | CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C |
其他名称 | UNC 2025, UNC-2025 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 88 mg/mL (184.62 mM) | |
Water | Insoluble | ||
Ethanol | 53 mg/mL | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 20.98 mL | 104.89 mL | 209.78 mL |
0.5 mM | 4.2 mL | 20.98 mL | 41.96 mL |
1 mM | 2.1 mL | 10.49 mL | 20.98 mL |
5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2