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UNC0642

促销

G9a/GLP 抑制剂

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产品目录号: A15487

库存状态:中国现货中国现货

产品名 目录号 价格 数量
UNC0642 10mg A15487-10
¥ 1,500.00
UNC0642 25mg A15487-25
¥ 3,000.00
UNC0642 50mg A15487-50
¥ 4,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

UNC0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). It reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo.

UNC0642

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Chemical Information

目录号 A15487
Mechanism of action Inhibitor
分子量 546.69
化学分子式 C29H44F2N6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1481677-78-4
Synonyms UNC 0642, UNC-0642
SMILES code CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F
化学名称 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine

生物活性

Description
UNC0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). It reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.29 mL 91.46 mL 182.92mL
0.5 mM 3.66 mL 18.29 mL 36.58 mL
1 mM 1.83 mL 9.15 mL 18.29 mL
5 mM 0.37 mL 1.83 mL 3.66 mL

*The above data is based on the productmolecular weight 546.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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