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UR 1102是一种肾尿酸转运蛋白URAT1的抑制剂，在体外对ORAT1和OAT3具有较高的对URAT1的选择性（Ki值分别为0.057 uM，7.2 uM和2.4 uM），能够增加尿酸的排泄分数并降低 血浆尿酸比苯溴马隆更有效。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.15 mL | 120.76 mL | 241.52 mL |
| 0.5 mM | 4.83 mL | 24.15 mL | 48.3 mL |
| 1 mM | 2.42 mL | 12.08 mL | 24.15 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.83 mL |
*The above data is based on the productmolecular weight 414.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16187 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 414.05 |
| Formula | C14H10Br2N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1198153-15-9 |
| Synonyms | UR-1102 |
| SMILES | C1COC2=C(N1C(=O)C3=CC(=C(C(=C3)Br)O)Br)C=NC=C2 |
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