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URMC-099

促销

MLK 抑制剂

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产品目录号: A14219

库存状态:中国现货中国现货

产品名 目录号 价格 数量
URMC-099 5mg A14219-5
¥ 700.00
URMC-099 10mg A14219-10
¥ 1,200.00
URMC-099 25mg A14219-25
¥ 2,200.00
URMC-099 10mM * 1mL in DMSO A14219-10mM-D
¥ 880.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.

URMC-099

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 URMC-099 发表的文献 (1)
  • Elad Prinz, .et al. WDR62 mediates TNF汐-dependent JNK activation via TRAF2-MLK3 axis, Mol Biol Cell, 2018, Oct 1; 29(20): 2470每2480 PMID: 30091641

Chemical Information

目录号 A14219
Mechanism of action Inhibitor
分子量 421.54
化学分子式 C27H27N5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1229582-33-5
Synonyms URMC 099,URMC099
SMILES code CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6
化学名称 3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine

生物活性

Description
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.
Targets
Target Value
Abl1IC50: 6.5nM
LRRK2IC50: 11nM
MLK3IC50: 14nM
MLK1IC50: 19nM
VEGFR1/FLT1IC50: 39nM
MLK2IC50: 42nM
SGKIC50: 67nM
TrkAIC50: 85nM
AuroraAIC50: 108nM
ROCK2IC50: 111nM
AuroraBIC50: 123nM
DLKIC50: 150nM
c-MetIC50: 177nM
IRIC50: 200nM
SGK1IC50: 201nM
TrkBIC50: 217nM
AuroraCIC50: 290nM
IGF-1RIC50: 307nM
LCKIC50: 333nM
MEKK2IC50: 661nM
SykIC50: 731nM
ROCK1IC50: 1030nM
CDK1IC50: 1125nM
CDK2IC50: 1180nM
AMPKIC50: 1512nM
JNK1IC50: 3280nM
SrcIC50: 4330nM
ZAP70IC50: 5050nM
ERK2IC50: 6290nM
GSK-3βIC50: >10000nM
p38αIC50: 12050nM

溶解性

Solubility (25°C)* In vitro DMSO 84 mg/mL (199.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol 84 mg/mL (199.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.72 mL 118.61 mL 237.23mL
0.5 mM 4.74 mL 23.72 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL

*The above data is based on the productmolecular weight 421.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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