Vandetanib (ZD6474)

Name: Vandetanib (ZD6474)
SKU: A10963
Price: 210 CNY
Rating: 5 (10 reviews)

目录号: A10963

VEGFR 抑制剂

10 篇发表文献

Vandetanib（Zactima）是一种 VEGFR 和 EGFR 拮抗剂，同时也是一种酪氨酸激酶抑制剂，其IC50分别为60、90、40 nM，针对HUVEC细胞增殖、PC-9细胞和酪氨酸激酶活性。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥280.00	现货
25mg	¥385.00	现货
50mg	¥630.00	现货
100mg	¥1,190.00	现货
200mg	¥1,680.00	现货
500mg	¥2,730.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Vandetanib (ZD6474)

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Vandetanib (ZD6474)发表的10篇文献

Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143

Shinya Kitamura, .et al. , Biochem Biophys Res Commun, 2020, Aug 13 PMID: 32800552

Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298

Rintaro Sogawa, .et al. , JPA, 2018, in Press PMID: 30740257

Park K, .et al. , Anat Sci Int, 2018, Jun;93(3):372-383 PMID: 29256114

Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Park K, .et al. , Biomed Pharmacother, 2016, Mar;78:140-149 PMID: 26898435

生物活性

Discription

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10963
分子式	C22H24BrFN4O2
分子量	475.4
CAS号	443913-73-3
SMILES	CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
其他名称	ZD6474
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	4 mg/mL (8.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.03 mL	105.17 mL	210.35 mL
0.5 mM	4.21 mL	21.03 mL	42.07 mL
1 mM	2.1 mL	10.52 mL	21.03 mL
5 mM	0.42 mL	2.1 mL	4.21 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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