Vandetanib (ZD6474)

目录号: A10963

VEGFR inhibitor

Vandetanib (ZD6474) Chemical Structure

CAS NO. 443913-73-3

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.

库存: 现货

规格 价格 数量
25 mg
¥ 600.00
50 mg
¥ 1,000.00
100 mg
¥ 2,000.00
500 mg
¥ 4,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
Targets
VEGFR2 (Cell-free assay)
40 nM
In vitro DMSO 4 mg/mL (8.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.03 mL 105.17 mL 210.35 mL
0.5 mM 4.21 mL 21.03 mL 42.07 mL
1 mM 2.1 mL 10.52 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL

*The above data is based on the productmolecular weight 475.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10963
MECHANISM OF ACTION Inhibitor
M. Wt 475.4
Formula C22H24BrFN4O2
Solubility DMSO>4mg/mL Water<1mg/mL Ethanol>3mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 443913-73-3
Synonyms ZD6474
SMILES CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

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