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产品目录号: A11605


产品名 目录号 价格 数量
VE-821 10mg A11605-10
¥ 1,100.00
VE-821 25mg A11605-25
¥ 2,000.00
VE-821 50mg A11605-50
¥ 3,500.00
VE-821 10mM * 1mL in DMSO A11605-10mM-D
¥ 800.00



VE-821 is a potent and selective inhibitor of protein kinase ATR.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 VE-821 发表的文献 (5)
  • Mitsuru Sasaki-Honda, .et al. A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4, Hum Mol Genet, 2018, Dec 1; 27(23): 4024每4035 PMID: 30107443
  • Kim J, .et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions, Mol Cell, 2018, Jan 4;69(1):36-47.e7 PMID: 29249653
  • Antonio Postigo, .et al. Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication, Cell Rep, 2017, May 2; 19(5): 1022每1032 PMID: 28467896
  • Nnennaya Kanu, .et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer, Genome Biol, 2016, 17: 185 PMID: 27634334
  • Carolyn Botting, .et al. H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication, Virol J, 2016, 13: 15 PMID: 26817608

Chemical Information

目录号 A11605
Mechanism of action Inhibitor
分子量 468.4
化学分子式 C18H16N4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1232410-49-9
Synonyms VE821
SMILES code CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N
化学名称 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide


VE-821 is a potent and selective inhibitor of protein kinase ATR.
ATR (Cell-free assay)
13 nM(Ki)


Solubility (25°C) * In vitro DMSO 74 mg/mL (200.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.35 mL 106.75 mL 213.49mL
0.5 mM 4.27 mL 21.35 mL 42.7 mL
1 mM 2.13 mL 10.67 mL 21.35 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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