Verubecestat (MK-8931)
目录号: A16113
β-secretase/BACE1 抑制剂
Verubecesta 是一种强效且选择性的beta-secretase抑制剂,同时也是BACE1蛋白抑制剂或Beta位点APP切割酶1抑制剂。
Discription | Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. |
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目录号 | A16113 |
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分子式 | C17H17F2N5O3S |
分子量 | 409.41 |
CAS号 | 1286770-55-5 |
SMILES | O=C(C1=NC=C(F)C=C1)NC2=CC=C(F)C([C@@](C3)(C)N=C(N)N(C)S3(=O)=O)=C2 |
其他名称 | MK-8931, MK 8931, MK8931 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 77 mg/mL (188.07 mM) | |
Water | Insoluble | ||
Ethanol | 39 mg/mL (95.26 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 24.43 mL | 122.13 mL | 244.25 mL |
0.5 mM | 4.89 mL | 24.43 mL | 48.85 mL |
1 mM | 2.44 mL | 12.21 mL | 24.43 mL |
5 mM | 0.49 mL | 2.44 mL | 4.89 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2