Vobramitamab is a humanized monoclonal antibody targeting B7-H3, conjugated to the prodrug seco-DUBA through a cleavable linker to create the antibody-drug conjugate (ADC) MGC018. This ADC has demonstrated potent antitumor efficacy in preclinical models across a variety of cancers, including breast, ovarian, lung cancer, and melanoma. MGC018's design allows for targeted delivery of the cytotoxic agent to tumor cells, minimizing systemic exposure and enhancing therapeutic potential.
Vobramitamab is a humanized monoclonal antibody targeting B7-H3, conjugated to the prodrug seco-DUBA through a cleavable linker to create the antibody-drug conjugate (ADC) MGC018. This ADC has demonstrated potent antitumor efficacy in preclinical models across a variety of cancers, including breast, ovarian, lung cancer, and melanoma. MGC018's design allows for targeted delivery of the cytotoxic agent to tumor cells, minimizing systemic exposure and enhancing therapeutic potential.
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