Vopratelimab (JTX-2011) is a humanized IgG1-kappa agonist monoclonal antibody designed to selectively target the Inducible T-cell CO-Stimulator (ICOS), a critical molecule in the modulation of T-cell activity. This antibody exhibits strong species cross-reactivity, demonstrating binding affinities of 0.93 nM for human ICOS, 0.46 nM for cynomolgus ICOS, 3.7 nM for rat ICOS, and 0.64 nM for murine ICOS. Vopratelimab is primarily utilized in research focused on enhancing antitumor immune responses, making it a valuable tool in oncology and immunotherapy studies.
Vopratelimab (JTX-2011) is a humanized IgG1-kappa agonist monoclonal antibody designed to selectively target the Inducible T-cell CO-Stimulator (ICOS), a critical molecule in the modulation of T-cell activity. This antibody exhibits strong species cross-reactivity, demonstrating binding affinities of 0.93 nM for human ICOS, 0.46 nM for cynomolgus ICOS, 3.7 nM for rat ICOS, and 0.64 nM for murine ICOS. Vopratelimab is primarily utilized in research focused on enhancing antitumor immune responses, making it a valuable tool in oncology and immunotherapy studies.
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