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Vorapaxar (SCH 530348)


PAR-1 拮抗剂

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产品目录号: A12832


产品名 目录号 价格 数量
Vorapaxar (SCH 530348) 5mg A12832-5
¥ 1,300.00
Vorapaxar (SCH 530348) 10mg A12832-10
¥ 2,300.00
Vorapaxar (SCH 530348) 25mg A12832-25
¥ 4,600.00
Vorapaxar (SCH 530348) 50mg A12832-50
¥ 6,800.00



Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

Vorapaxar (SCH 530348)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Vorapaxar (SCH 530348) 发表的文献 (5)
  • Cansu Tekin, .et al. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer, Oncotarget, 2018, Aug 10; 9(62): 32010每32023 PMID: 30174793
  • Claushuis TA, .et al. Thrombin contributes to protective immunity in pneumonia-derived sepsis via fibrin polymerization and platelet-neutrophil interactions, J Thromb Haemost, 2017, Apr;15(4):744-757 PMID: 28092405
  • Maaike Waasdorp, .et al. Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner, Biochem Biophys Rep, 2017, Jul; 10: 152每156 PMID: 29114573
  • Joseph C. Mudd, .et al. Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions, J Infect Dis, 2016, Dec 15; 214(12): 1808每1816 PMID: 27703039
  • Corey E. Tabit, .et al. Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Non-Surgical Bleeding, Circulation, 2016, Jul 12; 134(2): 141每152 PMID: 27354285

Chemical Information

目录号 A12832
Mechanism of action Antagonist
分子量 492.58
化学分子式 C29H33FN2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 618385-01-6
Synonyms SCH530348, SCH-530348, MK-5348, MK5348, MK 5348
SMILES code CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]3[C@H]([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[C@H](OC3=O)C
化学名称 Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester


Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
8.1 nM(Ki)


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.3 mL 101.51 mL 203.01mL
0.5 mM 4.06 mL 20.3 mL 40.6 mL
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL

*The above data is based on the productmolecular weight 492.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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