|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.|
|Solubility (25°C) *||In vitro||DMSO||53 mg/mL (200.52 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||3 mg/mL (11.35 mM)|
|In vivo||2% DMSO, 40% PEG 300, 5% propylene glycol, 1% Tween 80||5 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||37.84 mL||189.18 mL||378.36mL|
|0.5 mM||7.57 mL||37.84 mL||75.67 mL|
|1 mM||3.78 mL||18.92 mL||37.84 mL|
|5 mM||0.76 mL||3.78 mL||7.57 mL|
*The above data is based on the productmolecular weight 264.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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