VP3.15

目录号: A18538

dual PDE7/GSK-3 inhibitor

VP3.15

VP3.15 Chemical Structure

CAS NO. 1281681-54-6

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).

库存: 现货

规格 价格 数量
5 mg
¥ 3,500.00
10 mg
¥ 6,500.00
50 mg
¥ 20,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.29 mL 136.43 mL 272.87 mL
0.5 mM 5.46 mL 27.29 mL 54.57 mL
1 mM 2.73 mL 13.64 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A18538
作用机制 Inhibitor (抑制剂)
M. Wt 366.48
Formula C20H22N4OS
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1281681-54-6
Synonyms VP315, VP-3.15
SMILES N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1

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