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VX-222是HCV NS5B聚合酶的小分子非核苷抑制剂，正在研究中，用于治疗丙型肝炎病毒感染。
靶点信息
| HCV NS5B 1a | HCV NS5B 1b | |||
| 0.94 μM | 1.2 μM |
| In vitro (25°C) | DMSO | 76 mg/mL (170.55 mM) | |
| Water | Insoluble | ||
| Ethanol | 76 mg/mL (170.55 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.44 mL | 112.21 mL | 224.42 mL |
| 0.5 mM | 4.49 mL | 22.44 mL | 44.88 mL |
| 1 mM | 2.24 mL | 11.22 mL | 22.44 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.49 mL |
*The above data is based on the productmolecular weight 445.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10980 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 445.6 |
| Formula | C25H35NO4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1026785-59-0 |
| Synonyms | VCH222, VX222 |
| SMILES | CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O |
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