VX-680 (MK-0457, Tozasertib)

目录号: A10981

Aurora Kinase inhibitor

VX-680 (MK-0457, Tozasertib) Chemical Structure

CAS NO. 639089-54-6

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

库存: 现货

规格 价格 数量
25 mg
¥ 400.00
50 mg
¥ 600.00
100 mg
¥ 1,000.00
250 mg
¥ 2,000.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.
Targets
Aurora A (Cell-free assay) Aurora C (Cell-free assay) Aurora B (Cell-free assay) FLT3 (Cell-free assay) Bcr-Abl (Cell-free assay)
0.6 nM(Ki app)4.6 nM(Ki app)18 nM(Ki app)30 nM(Ki)30 nM(Ki)
In vitro (25°C) DMSO 93 mg/mL (200.17 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.52 mL 107.62 mL 215.24 mL
0.5 mM 4.3 mL 21.52 mL 43.05 mL
1 mM 2.15 mL 10.76 mL 21.52 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 464.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10981
MECHANISM OF ACTION Inhibitor
M. Wt 464.6
Formula C23H28N8OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 639089-54-6
Synonyms N/A
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

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