VX-745

目录号: A10983

p38 MAPK inhibitor

VX-745 Chemical Structure

CAS NO. 209410-46-8

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 900.00
50 mg
¥ 3,600.00
100 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 1,200.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
靶点信息
p38α p38β
10 nM220 nM
In vitro (25°C) DMSO 15 mg/mL (34.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.92 mL 114.6 mL 229.2 mL
0.5 mM 4.58 mL 22.92 mL 45.84 mL
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10983
MECHANISM OF ACTION Inhibitor
M. Wt 436.3
Formula C19H9Cl2F2N3OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 209410-46-8
Synonyms VX745
SMILES C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl

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