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p38 MAPK 抑制剂

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产品目录号: A10983


产品名 目录号 价格 数量
VX-745 5mg A10983-5
¥ 600.00
VX-745 10mg A10983-10
¥ 900.00
VX-745 50mg A10983-50
¥ 3,600.00
VX-745 100mg A10983-100
¥ 6,000.00
VX-745 10mM * 1mL in DMSO A10983-10mM-D
¥ 1,200.00



VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .





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Chemical Information

目录号 A10983
Mechanism of action Inhibitor
分子量 436.3
化学分子式 C19H9Cl2F2N3OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 209410-46-8
Synonyms VX745
SMILES code C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
化学名称 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one


VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
p38α p38β
10 nM220 nM


Solubility (25°C) * In vitro DMSO 15 mg/mL (34.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.92 mL 114.6 mL 229.2mL
0.5 mM 4.58 mL 22.92 mL 45.84 mL
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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