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VX-765 (Belnacasan)

促销

Caspase-1/4 抑制剂

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产品目录号: A10984

库存状态:中国现货中国现货

产品名 目录号 价格 数量
VX-765 5mg A10984-5
¥ 700.00
VX-765 10mg A10984-10
¥ 980.00
VX-765 50mg A10984-50
¥ 2,500.00
VX-765 100mg A10984-100
¥ 4,500.00
VX-765 10mM * 1mL in DMSO A10984-10mM-D
¥ 750.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

VX-765 (Belnacasan)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 VX-765 (Belnacasan) 发表的文献 (4)
  • Joseph Flores, .et al. Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer*s disease mouse model, Nat Commun, 2018, 9: 3916 PMID: 30254377
  • Mohamed F. Ali, .et al. Canonical Stimulation of the NLRP3 Inflammasome by Fungal Antigens Links Innate and Adaptive B-Lymphocyte Responses by Modulating IL-1汕 and IgM Production, Front Immunol, 2017, 8: 1504 PMID: 29170665
  • Garc赤a-Fern芍ndez A, .et al. Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles, J Control Release, 2017, Feb 28;248:60-70 PMID: 28069553
  • Jiujiu Yu, .et al. Inflammasome activation leads to Caspase-1每 dependent mitochondrial damage and block of mitophagy, Proc Natl Acad Sci U S A., 2014, 111(43): 15514每15519 PMID: 25313054

Chemical Information

目录号 A10984
Mechanism of action Inhibitor
分子量 509.0
化学分子式 C24H33ClN4O6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 273404-37-8
Synonyms VX765
SMILES code CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
化学名称 (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide

生物活性

Description
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
Targets
Caspase-4 (Cell-free assay) Caspase-1 (Cell-free assay)
<0.6 nM(Ki)0.8 nM(Ki)

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL heating (196.46 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL heating (196.46 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.65 mL 98.23 mL 196.46mL
0.5 mM 3.93 mL 19.65 mL 39.29 mL
1 mM 1.96 mL 9.82 mL 19.65 mL
5 mM 0.39 mL 1.96 mL 3.93 mL

*The above data is based on the productmolecular weight 509.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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