VX-809 (Lumacaftor)

Name: VX-809 (Lumacaftor)
SKU: A10986
Price: 245 CNY
Rating: 5 (6 reviews)

目录号: A10986

CFTR modulator

6 篇发表文献

VX-809 是第二个用于治疗囊性纤维化（CF）的口服候选化合物。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥385.00	现货
25mg	¥490.00	现货
50mg	¥630.00	现货
100mg	¥840.00	现货
500mg	¥2,135.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用VX-809 (Lumacaftor)发表的6篇文献

Danny D Dinh, .et al. , EBioMedicine, 2024, Apr:102:105058 PMID: 38490104

Daichi Hinata, .et al. , Int J Mol Sci, 2023, Jan 24;24(3):2305 PMID: 36768629

Kusumika Saha, .et al. , Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862

Heledd H Jarosz-Griffiths, .et al. , Elife, 2020, Mar 2;9:e54556 PMID: 32118580

Okiyoneda T, .et al. , Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157

Junko Kido, .et al. , Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926

生物活性

Discription

VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).

Targets

Target	Value

产品信息

目录号	A10986
分子式	C24H18F2N2O5
分子量	452.4
CAS号	936727-05-8
SMILES	CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
其他名称	VX809
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	88 mg/mL (194.51 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (13.26 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.1 mL	110.52 mL	221.04 mL
0.5 mM	4.42 mL	22.1 mL	44.21 mL
1 mM	2.21 mL	11.05 mL	22.1 mL
5 mM	0.44 mL	2.21 mL	4.42 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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