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PI3K 抑制剂

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产品目录号: A11161


产品名 目录号 价格 数量
Wortmannin 5mg A11161-5
¥ 800.00
Wortmannin 10mg A11161-10
¥ 1,100.00
Wortmannin 25mg A11161-25
¥ 2,400.00
Wortmannin 50mg A11161-50
¥ 3,800.00
Wortmannin 10mM * 1mL in DMSO A11161-10mM-D
¥ 850.00



Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).





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Chemical Information

目录号 A11161
Mechanism of action Inhibitor
分子量 428.43
化学分子式 C23H24O8
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 19545-26-7
Synonyms SL-2052
SMILES code CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
化学名称 (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-f uro[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6, 9-trione



Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

PI3K (Cell-free assay) DNA-PK [12](Cell-free assay) ATM [12](Cell-free assay) MLCK (Cell-free assay) ATR [12](Cell-free assay)
3 nM16 nM150 nM170 nM1.8 μM


Solubility (25°C) * In vitro DMSO 86 mg/mL (200.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.71 mL 233.41mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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