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WP1066是一种新型的JAK2抑制剂，可抑制携带JAK2 V617F突变的类人甲状腺细胞增殖并诱导其凋亡。
靶点信息
| JAK2 (HEL cells) | STAT3 (HEL cells) | |||
| 2.3 μM | 2.43 μM |
| In vitro | DMSO | 64 mg/mL (179.66 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.07 mL | 140.37 mL | 280.74 mL |
| 0.5 mM | 5.61 mL | 28.07 mL | 56.15 mL |
| 1 mM | 2.81 mL | 14.04 mL | 28.07 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
*The above data is based on the productmolecular weight 356.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11795 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 356.2 |
| Formula | C17H14BrN3O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 857064-38-1 |
| Synonyms | WP 1066, WP-1066 |
| SMILES | C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N |
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