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JAK 抑制剂

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产品目录号: A11795


产品名 目录号 价格 数量
WP1066 10mg A11795-10
¥ 600.00
WP1066 25mg A11795-25
¥ 1,400.00
WP1066 50mg A11795-50
¥ 2,100.00
WP1066 10mM * 1mL in DMSO A11795-10mM-D
¥ 700.00



WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.





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Chemical Information

目录号 A11795
Mechanism of action Inhibitor
分子量 356.2
化学分子式 C17H14BrN3O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 857064-38-1
Synonyms WP 1066, WP-1066
SMILES code C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
化学名称 (E)-3(6-bromopyridin-2-yl)-2-cyano-N-(S0-1phenylethyl)acrylamide


WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.
JAK2 (HEL cells) STAT3 (HEL cells)
2.3 μM2.43 μM


Solubility (25°C)* In vitro DMSO 71 mg/mL (199.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.07 mL 140.37 mL 280.74mL
0.5 mM 5.61 mL 28.07 mL 56.15 mL
1 mM 2.81 mL 14.04 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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