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WP1066

促销

JAK 抑制剂

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产品目录号: A11795

库存状态:中国现货中国现货

产品名 目录号 价格 数量
WP1066 10mg A11795-10
¥ 600.00
WP1066 25mg A11795-25
¥ 1,400.00
WP1066 50mg A11795-50
¥ 2,100.00
WP1066 10mM * 1mL in DMSO A11795-10mM-D
¥ 700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.

WP1066

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Chemical Information

目录号 A11795
Mechanism of action Inhibitor
分子量 356.2
化学分子式 C17H14BrN3O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 857064-38-1
Synonyms WP 1066, WP-1066
SMILES code C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
化学名称 (E)-3(6-bromopyridin-2-yl)-2-cyano-N-(S0-1phenylethyl)acrylamide

生物活性

Description
WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.
Targets
JAK2 (HEL cells) STAT3 (HEL cells)
2.3 μM2.43 μM

溶解性

Solubility (25°C)* In vitro DMSO 71 mg/mL (199.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.07 mL 140.37 mL 280.74mL
0.5 mM 5.61 mL 28.07 mL 56.15 mL
1 mM 2.81 mL 14.04 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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