WP1130 (Degrasyn)

Name: WP1130 (Degrasyn)
SKU: A10988

目录号: A10988

DUB/Bcr/ABL 抑制剂

WP1130 (Degrasyn) Chemical Structure

CAS NO. 856243-80-6

WP1130 (Degrasyn)是一种新型的选择性小分子去泛素酶抑制剂和Bcr/Abl破坏途径激活剂，可特异性和快速下调野生型和突变型Bcr/Abl蛋白，而不会影响慢性粒细胞性白血病（CML）中的bcr/abl基因表达细胞。

库存：现货

规格	价格	数量
5 mg	￥ 600.00
10 mg	￥ 1,000.00
50 mg	￥ 2,800.00
100 mg	￥ 4,500.00
10mM * 1mL in DMSO	￥ 1,050.00

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产品详情

生物活性

靶点信息

DUB (Cell-free assay)	Bcr-Abl (Cell-free assay)
N/A	1.8 μM

溶解度 *

In vitro	DMSO	73 mg/mL (189.96 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (44.24 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.02 mL	130.11 mL	260.21 mL
0.5 mM	5.2 mL	26.02 mL	52.04 mL
1 mM	2.6 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10988
作用机制	Inhibitor (抑制剂)
M. Wt	384.3
Formula	C19H18BrN3O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	856243-80-6
Synonyms	WP-1130, Degrasyn
SMILES	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N