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WYE-354 (Degrasyn)


mTOR 抑制剂

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产品目录号: A10989


产品名 目录号 价格 数量
WYE-354 5mg A10989-5
¥ 600.00
WYE-354 10mg A10989-10
¥ 1,000.00
WYE-354 25mg A10989-25
¥ 2,200.00
WYE-354 50mg A10989-50
¥ 4,000.00
WYE-354 10mM * 1mL in DMSO A10989-10mM-D
¥ 1,180.00



WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.

WYE-354 (Degrasyn)




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Chemical Information

目录号 A10989
Mechanism of action Inhibitor
分子量 495.5
化学分子式 C24H29N7O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1062169-56-5
Synonyms WYE354
化学名称 4-​[6-​[4-​[(methoxycarbonyl)amino]phenyl]-​4-​(4-​morpholinyl)-​1H-​pyrazolo[3,​4-​d]pyrimidin-​1-​yl]-​methyl ester-​1-​piperidinecarboxylic acid


WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
Target Value
mTORIC50: 5nM
PI3KαIC50: 1.89μM
PI3KγIC50: 7.37μM
GCKIC50: >50μM
HckIC50: >50μM
IKKαIC50: >50μM
LynIC50: >50μM
MetIC50: >50μM
MK2IC50: >50μM
p38αIC50: >50μM
PDGFRαIC50: >50μM
PKAIC50: >50μM
PKBαIC50: >50μM
PKCαIC50: >50μM
PKCβIC50: >50μM
ROCK1IC50: >50μM
RSK1IC50: >50μM
SrcIC50: >50μM
VEGFR2IC50: >50μM
Abl1IC50: >50μM
AuroraBIC50: >50μM
CDK1/CyclinBIC50: >50μM
CDK2/CyclinAIC50: >50μM
Chk1IC50: >50μM
ERK2IC50: >50μM
FynIC50: >50μM


Solubility (25°C) * In vitro DMSO 99 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.91 mL 201.82mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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