WYE-354

WYE-354 Chemical Structure

CAS NO. 1062169-56-5

WYE-354是一种有效的mTOR细胞渗透抑制剂(IC50 = 4.3 nM),可阻断通过mTOR复合体1(mTORC1)和mTORC2的信号传导。它是PI3Kα(IC50 = 1026 nM)和其他激酶的弱得多的抑制剂。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
25 mg
¥ 2,200.00
50 mg
¥ 4,000.00
10mM * 1mL in DMSO
¥ 1,180.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

WYE-354是一种有效的mTOR细胞渗透抑制剂(IC50 = 4.3 nM),可阻断通过mTOR复合体1(mTORC1)和mTORC2的信号传导。它是PI3Kα(IC50 = 1026 nM)和其他激酶的弱得多的抑制剂。
Targets
Target Value
mTORIC50: 5nM
PI3KαIC50: 1.89μM
PI3KγIC50: 7.37μM
GCKIC50: >50μM
HckIC50: >50μM
IKKαIC50: >50μM
LynIC50: >50μM
MetIC50: >50μM
MK2IC50: >50μM
p38αIC50: >50μM
PDGFRαIC50: >50μM
PKAIC50: >50μM
PKBαIC50: >50μM
PKCαIC50: >50μM
PKCβIC50: >50μM
ROCK1IC50: >50μM
RSK1IC50: >50μM
SrcIC50: >50μM
VEGFR2IC50: >50μM
Abl1IC50: >50μM
AuroraBIC50: >50μM
CDK1/CyclinBIC50: >50μM
CDK2/CyclinAIC50: >50μM
Chk1IC50: >50μM
ERK2IC50: >50μM
FynIC50: >50μM
In vitro (25°C) DMSO 99 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.91 mL 201.82 mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10989
作用机制 Inhibitor (抑制剂)
M. Wt 495.5
Formula C24H29N7O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1062169-56-5
Synonyms WYE354
SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

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