WZ3146

目录号: A10990

EGFR Inhibitor

WZ3146

WZ3146 Chemical Structure

CAS NO. 1214265-56-1

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,200.00
50 mg
¥ 3,500.00
100 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 1,240.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
Targets
EGFR (L858R) EGFR (E746_A750) EGFR (L858R/T790M) EGFR (E746_A750/T790M)
2 nM2 nM5 nM14 nM
In vitro DMSO 93 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.51 mL 107.53 mL 215.05 mL
0.5 mM 4.3 mL 21.51 mL 43.01 mL
1 mM 2.15 mL 10.75 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10990
MECHANISM OF ACTION Inhibitor
M. Wt 465.0
Formula C24H25ClN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1214265-56-1
Synonyms WZ-3146
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

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