产品详情
靶点信息
EGFR (L858R) (BaF3 cells) | EGFR (L858R/T790M) (BaF3 cells) | |||
2 nM | 8 nM |
In vitro (25°C) | DMSO | 12 mg/mL (24.28 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.2 mL | 101.01 mL | 202.02 mL |
0.5 mM | 4.04 mL | 20.2 mL | 40.4 mL |
1 mM | 2.02 mL | 10.1 mL | 20.2 mL |
5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
*The above data is based on the productmolecular weight 495.0. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10991 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 495.0 |
Formula | C25H27ClN6O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1213269-23-8 |
SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC |
产品标签
Product Questions
Product Questions
PD153035 (HCl salt)
PD153035 (HCl salt)是EGFR酪氨酸激酶活性的极其有效和特异的抑制剂。
ARRY-543 (Varlitinib, ASLAN001)
ARRY-543 (Varlitinib,ASLAN001)是一种新型口服ErbB家族抑制剂,与批准的ErbB抑制剂不同,它直接或间接靶向ErbB家…
Neratinib (HKI-272)
Neratinib (HKI-272)是一种酪氨酸激酶抑制剂。
XL647 (Tesevatinib)
XL647 (Tesevatinib)是一种口服生物可利用的小分子RTK抑制剂,可结合并抑制在肿瘤细胞增殖和肿瘤血管形成中…
ASP8273 (Naquotinib)
ASP8273 (Naquotinib)是不可逆的,第三代,选择性突变的表皮生长因子受体(EGFR)抑制剂,具有潜在的抗肿瘤…