XEN445

Name: XEN445
SKU: A13150
Price: 140 CNY
Rating: 5 (288 reviews)

目录号: A13150

Endothelial lipase(EL) 抑制剂

XEN445 是一种强效且选择性的 EL 抑制剂（IC50=0.237 uM），表现出良好的 ADME 和 PK 特性，并在小鼠体内有效提高血浆 HDLc 浓度。

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Grouped product items
规格	价格	库存
2mg	¥140.00	现货
5mg	¥210.00	现货
10mg	¥385.00	现货
25mg	¥770.00	现货
50mg	¥1,505.00	现货
100mg	¥2,345.00	现货
200mg	¥3,360.00	现货
*10mM 1mL in DMSO**	¥210.00	现货
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Data Sheet

SDS

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生物活性

Discription

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13150
分子式	C18H17F3N2O3
分子量	366.33
CAS号	1515856-92-4
SMILES	C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
其他名称	XEN-445, XEN 445
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	79 mg/mL (215.65 mM)
	Water	Insoluble
	Ethanol	Warmed: 34 mg/mL (92.81 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.3 mL	136.49 mL	272.98 mL
0.5 mM	5.46 mL	27.3 mL	54.6 mL
1 mM	2.73 mL	13.65 mL	27.3 mL
5 mM	0.55 mL	2.73 mL	5.46 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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