XEN445

目录号: A13150

Endothelial lipase(EL) inhibitor

XEN445

XEN445 Chemical Structure

CAS NO. 1515856-92-4

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.

库存: 现货

规格 价格 数量
10mM * 1mL in DMSO
¥ 400.00
10mM * 1mL in DMSO
¥ 700.00
10 mg
¥ 1,300.00
10mM * 1mL in DMSO
¥ 1,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
Targets
Targets
endothelial lipase
0.237 μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.3 mL 136.49 mL 272.98 mL
0.5 mM 5.46 mL 27.3 mL 54.6 mL
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13150
MECHANISM OF ACTION Inhibitor
M. Wt 366.33
Formula C18H17F3N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1515856-92-4
Synonyms XEN-445, XEN 445
SMILES C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O

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